Thebrain 9 keygen4/16/2023 ![]() Although it is newly emerging, complex connectivity and network analysis is not only possible, but has also been shown to be reliable and reproducible in the spinal cord for both task-based and resting-state studies. ![]() We, therefore, discuss the similarities and differences of these to resting-state fMRI and gradient-echo EPI protocols. The literature also demonstrates clear trends in study design and acquisition methods, as the majority of studies follow a task-based, block design paradigm, and utilize variations of single-shot fast spin-echo imaging methods. Applications of spinal fMRI span from animal models across healthy and patient populations in humans using both task-based and resting-state paradigms. Animal models have served a key purpose for the development of spinal fMRI protocols and for experimental spinal cord injury studies. We discuss 10 key points regarding the history, development, methods, and applications of spinal fMRI. ![]() Spinal fMRI has been shown, over more than two decades of work, to be a reliable tool for detecting neural activity. A comprehensive review of the literature-to-date on functional magnetic resonance imaging (fMRI) of the spinal cord is presented.
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